Missing links between histones and RNA Pol II arising from SAND?
نویسندگان
چکیده
منابع مشابه
A myosin for RNA Pol II
A myosin for RNA Pol II T ranscription gets a boost from myosin VI, according to fi ndings from Sarah Vreugde (DIBIT Scientifi c Institute, Milano, Italy) and colleagues. The motor might drag genes into transcription neighborhoods. While trying to understand the function of myosin VI, Vreugde noticed that its localization pattern looked much like that of RNA polymerase II. The authors then show...
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a Alibaba Research Center for Complexity Sciences, Alibaba Business College, Hangzhou Normal University, Hangzhou 311121, PR China b Guangdong Province Key Laboratory of Popular High Performance Computers, College of Computer Science and Software Engineering, Shenzhen University, Shenzhen 518060, PR China c Department of Physics, University of Fribourg, Chemin du Musée 3, CH-1700 Fribourg, Swit...
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Gene expression is a process integral to cell proliferation. The E2F family of transcription factors upregulates expression of transcripts whose products are essential for cell cycle progression. Here, we report that E2F1 promotes gene expression by an additional mechanism, that is, formation of the methyl cap on RNA pol II transcripts. The methyl cap is required for mRNA maturation, expression...
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We describe the temporal order of recruitment of transcription factors, cofactors and basal transcriptional components and the consequent biochemical events that lead to activation of the major histocompatibility class II (MHCII) DRA gene transcription by IFN-gamma. We found that the gene is 'poised' for activation since both the activators and a fraction of the basal transcriptional machinery ...
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Cdc48/p97 is an essential ATPase whose role in targeting substrates to the ubiquitin-proteasome system (UPS) remains unclear. Existing models posit that Cdc48 acts upstream of UPS receptors. To address this hypothesis, we examined the association of ubiquitin (Ub) conjugates with 26S proteasomes. Unexpectedly, proteasomes isolated from cdc48 mutants contain high levels of Ub conjugates, and mas...
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ژورنال
عنوان ژورنال: Epigenetics
سال: 2010
ISSN: 1559-2294,1559-2308
DOI: 10.4161/epi.5.5.11956